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As reviewed by Hitchler et al., the intracellular redox chemistry has the potential to generate significant alterations in the epigenetic landscape through GSH and iron ions, which curtail the accessibility of epigenetic co-factors including S -adenosylmethionine (SAM), α-ketoglutarate, ascorbate, and nicotine adenine dinucleotide (NAD + ) (Hitchler and Domann, 2021)
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