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In oncology, integrate redox proteomics (PTP/cysteine-switch signatures), peroxiredoxin redox states and lipid-peroxide markers to time source-targeted ROS amplification (e.g., radiotherapy/chemotherapy plus ferroptosis inducers) versus node inhibition (NOX, FSP1/CoQ circuits) (Chen et al
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Therefore, inhibition of the cysteine cell transporter system xc− (cystine/glutamate antiporter protein SLC7A11) can lead to GSH depletion and cell death through ferroptosis
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