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Potential mechanisms of augmented IGF-2 expression in HCC were also described and dysregulation of IGF signaling in HCC was concluded to occur predominantly at the level of IGF-2 bioavailability
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This view shows clearly that tumors are not a collection of homogeneous cells with equal capacity for proliferation but rather a heterogeneous assembly consisting of differently functioning cells working together to maintain tumor growth as a pathophysiological organ
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