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INO, derived from ADO or IMP via ADA, has context-dependent immune effects ( These ectoenzymes, expressed by resident cells (44), sustain the CD38/CD203a/CD73 pathway ( Figure 1 ), which sequentially generates ADPR, AMP, and ultimately immunosuppressive ADO (45), thereby linking purinergic metabolism to immune evasion (44, 46, 47)
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